This survey looked at a number of factors and came up with a number for general well-being. There's a color-coded map and you can look at it by Congressional district or state. One thing jumped out at me: the most consistently contiguous section of unhappy people is in a stripe running from Appalachia then trending west through Kentucky, Tennessee, Arkansas and Oklahoma. It matches very closely with the only part of the country that voted more Republican for president in 2008. Coincidence?